Enhanced expression of the alpha7beta1 integrin reduces muscular dystrophy and restores viability in dystrophic mice.
Burkin DJ , Wallace GQ, Nicol KJ, Kaufman DJ, Kaufman SJ.
J Cell Biol. 2001 Mar 19;152(6):1207-18. PMID:11257121 [PubMed - indexed for MEDLINE] Free PMC Article

Transgenic expression of alpha7beta1 integrin maintains muscle integrity, increases regenerative capacity, promotes hypertrophy, and reduces cardiomyopathy in dystrophic mice.
Burkin DJ, Wallace GQ, Milner DJ, Chaney EJ, Mulligan JA, Kaufman SJ.
Am J Pathol. 2005 Jan;166(1):253-63. PMID:15632017[PubMed - indexed for MEDLINE] Free PMC Article

Severe muscular dystrophy in mice that lack dystrophin and alpha7 integrin.
Rooney JE, Welser JV, Dechert MA, Flintoff-Dye NL, Kaufman SJ, Burkin DJ.
J Cell Sci. 2006 Jun 1;119(Pt 11):2185-95. Epub 2006 May 9. PMID:16684813[PubMed - indexed for MEDLINE] Free Article

Increasing alpha7beta1-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expression.
Liu J, Burkin DJ , Kaufman SJ.
Am J Physiol Cell Physiol. 2008 Feb;294(2):C627-40. Epub 2007 Nov 28. PMID:18045857[PubMed - indexed for MEDLINE] Free PMC Article

Exercise promotes alpha7 integrin gene transcription and protection of skeletal muscle.
Boppart MD, Volker SE, Alexander N, Burkin DJ , Kaufman SJ.
Am J Physiol Regul Integr Comp Physiol. 2008 Nov;295(5):R1623-30. doi: 10.1152/ajpregu.00089.2008. Epub 2008 Sep 10.PMID:18784336[PubMed - indexed for MEDLINE] Free PMC Article

Valproic acid activates the PI3K/Akt/mTOR pathway in muscle and ameliorates pathology in a mouse model of Duchenne muscular dystrophy.
Gurpur PB, Liu J, Burkin DJ, Kaufman SJ.
Am J Pathol. 2009 Mar;174(3):999-1008. doi: 10.2353/ajpath.2009.080537. Epub 2009 Jan 29. PMID:19179609[PubMed - indexed for MEDLINE] Free PMC Article

Transgenic overexpression of the α7 integrin reduces muscle pathology and improves viability in the dy(W) mouse model of merosin-deficient congenital muscular dystrophy type 1A.
Doe JA, Wuebbles RD , Allred ET, Rooney JE, Elorza M, Burkin DJ.
J Cell Sci. 2011 Jul 1;124(Pt 13):2287-97. doi: 10.1242/jcs.083311. Epub 2011 Jun 7.PMID:21652631[PubMed - indexed for MEDLINE] Free PMC Article

Activation of AKT signaling promotes cell growth and survival in α7β1 integrin-mediated alleviation of muscular dystrophy.
Boppart MD, Burkin DJ, Kaufman SJ.
Biochim Biophys Acta. 2011 Apr;1812(4):439-46. doi: 10.1016/j.bbadis.2011.01.002. Epub 2011 Jan 7. PMID:21216283[PubMed - indexed for MEDLINE] Free PMC Article

Dystrophin and utrophin expression require sarcospan: loss of α7 integrin exacerbates a newly discovered muscle phenotype in sarcospan-null mice.
Marshall JL, Chou E, Oh J, Kwok A, Burkin DJ, Crosbie-Watson RH.
Hum Mol Genet. 2012 Oct 15;21(20):4378-93. Epub 2012 Jul 13.PMID:22798625[PubMed - indexed for MEDLINE] Free PMC Article

Alpha7 integrin preserves the function of the extensor digitorum longus muscle in dystrophin-null mice.
Hakim CH, Burkin DJ, Duan D.
J Appl Physiol (1985). 2013 Nov;115(9):1388-92. doi: 10.1152/japplphysiol.00602.2013. Epub 2013 Aug 29. PMID:23990247[PubMed - in process]

Levels of α7 integrin and laminin-α2 are increased following prednisone treatment in the mdx mouse and GRMD dog models of Duchenne muscular dystrophy.
Wuebbles RD, Sarathy A, Kornegay JN, Burkin DJ.
Dis Model Mech. 2013 Sep;6(5):1175-84. doi: 10.1242/dmm.012211. Epub 2013 Jul 11. PMID:23846963[PubMed - in process] Free PMC Article

AAV-mediated overexpression of human α7 integrin leads to histological and functional improvement in dystrophic mice.
Heller KN, Montgomery CL, Janssen PM, Clark KR, Mendell JR, Rodino-Klapac LR.
Mol Ther. 2013 Mar;21(3):520-5. doi: 10.1038/mt.2012.281. Epub 2013 Jan 15. PMID:23319059[PubMed - indexed for MEDLINE]